Thursday, February 15, 2018 - 1:30pm - 2:30pm
Theoden Netoff (University of Minnesota, Twin Cities)
The dynamics of spreading depolarizations (SD) operate at both the single cell and network level. As single cells bifurcate into extreme regions of their state space, network effects are all that remain to hold back the forthcoming wave of depolarization. Therefore, we investigated excitatory/inhibitory network effects near the leading edge of spreading depolarizations. We imaged >1000 layer 2/3 pyramidal neurons in vivo with GCaMP6f in awake mice before, during and after spreading depolarizations.
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