Monday, February 12, 2018 - 3:00pm - 4:00pm
Alan Kay (The University of Iowa)
Impermeant molecules in the cytoplasm set the stage for an osmotic imbalance in cells. In 1960 Tosteson & Hoffman (J.Gen.Physiol, 44:169-194) demonstrated how the operation of a sodium pump, by the so-called pump-leak mechanism (PLM), can stave off an osmotic catastrophe, where water flows into the cell until it bursts. In this presentation I will explore some of the implications of the PLM in regulating cell volume under normal and pathological conditions in the brain. Here are some of the questions that I will consider: What are the roles of aquaporin channels?
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