ion transport

Wednesday, March 14, 2018 - 2:00pm - 2:50pm
Richard Braun (University of Delaware)
We extend prior models for ion and water transport in corneal epithelial cells by Levin et al. [Invest. Ophthalmol. Vis. Sci. (2006) 47(1):306-316; (2004) 45(12):4423-4432] in order to determine their interaction with a thinning and hyperosmotic tear film. Each cell is considered as a compartment, and there is no variation along this hypothetical cornea. Thus, the cornea is approximated a stack of compartments with the tear film at the most anterior end, and a sequence of compartments representing cells extends posteriorly from the tear film.
Monday, February 12, 2018 - 3:00pm - 4:00pm
Alan Kay (The University of Iowa)
Impermeant molecules in the cytoplasm set the stage for an osmotic imbalance in cells. In 1960 Tosteson & Hoffman (J.Gen.Physiol, 44:169-194) demonstrated how the operation of a sodium pump, by the so-called pump-leak mechanism (PLM), can stave off an osmotic catastrophe, where water flows into the cell until it bursts. In this presentation I will explore some of the implications of the PLM in regulating cell volume under normal and pathological conditions in the brain. Here are some of the questions that I will consider: What are the roles of aquaporin channels?
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