Thursday, May 31, 2018 - 10:00am - 10:50am
Karin Leiderman (Colorado School of Mines)
Thrombin is an enzyme that plays many roles in the clotting process; it is associated with multiple positive and negative feedback loops and cleaves the soluble protein fibrinogen into fibrin, which polymerizes to form a stabilizing gel matrix in and around a growing blood clot. Another important role is binding to the fibrin matrix, but it is not yet understood whether this role has beneficial and/or pathological consequences; both have been hypothesized.
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