drug resistance

Wednesday, June 6, 2018 - 11:00am - 11:30am
Jasmine Foo (University of Minnesota, Twin Cities)
It has been observed experimentally that epigenetic phenomena can induce temporary or reversible drug-resistant phenotypes in cancer cell populations. For example, changes in methylation status of DNA repair genes may impact the responsiveness of cells to chemotherapies. Although these phenomena may be transient, they can have lasting impact on the genetic evolution of a tumor. Short-term epigenetic adaptations may serve as temporary lifelines for a population until more permanent genetic resistance mechanisms can be established.
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