Mediation analysis has been commonly used to study the effect of an exposure on an outcome through a mediator. In practice, we may face the problem to estimate and test a specific mediator of interest, termed “targeted mediator, in the presence of high dimensional mediators. In this talk we present a de-biased Lasso estimate for the targeted mediator and derive its standard error estimator, which can be used to develop a test procedure for the targeted mediation effect. Extensive simulation studies are conducted to assess the performance of our method.
