Biology occurs in concentrated mixtures of ions that are far from ideal. Solutions are remarkably concentrated where they are most important. Multi-molar solutions (often >10M) are found in and near DNA & RNA, proteins, active sites of enzymes, transporters, and ion channels, as well as electrodes of batteries. Poisson Boltzmann treatments fail dramatically to deal with the upper bound of concentration produced by the finite size of ions and so cannot describe ionic solutions of life, or ions where they are most important.