Virtual Patients

Wednesday, March 7, 2018 - 2:00pm - 3:00pm
Benyamin Grosman (Medtronic)
Background: The CareLink™ database has been used to generate a large number of virtual patients that can be used for in silico testing.
Methods: Each virtual subject was trained from 20 days of CareLink™ data. Using data from the ASPIRE Clinical Trial 1 and from the MiniMed™ 670G hybrid closed-loop (HCL) study 2 , the virtual patients were validated. Insulin action speed and meal absorption rates used in the mathematical model were validated with published literature. Thereafter, a mathematical model was developed with a tailored parametric optimization method.
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