Spreading Depression

Monday, February 12, 2018 - 1:30pm - 2:30pm
Steven Schiff (The Pennsylvania State University)
There is a several decade history demonstrating that electrical polarization of neurons can modulate neuronal firing, and that such polarization can suppress (or excite) spiking activity and seizures. In recent years, we uncovered a unification in the computational biophysics of spikes, seizures, and spreading depression (Wei et al J Neurosci 34:11733-11743, 2014).
Wednesday, February 14, 2018 - 1:30pm - 2:30pm
Yina Wei (University of California, San Diego)
The brain consumes 20% of the body’s metabolic energy with muscles and digestive system at rest, despite being only 2% of the human body mass. The majority of the brain’s metabolic energy is dedicated to restoring ionic gradients due to neuronal activities. The delicate balance between metabolic energy supply and expenditure becomes critically strained in pathological activity of the brain such as seizure and spreading depression, during which requires massive rearrangement of ions across the plasma membrane.
Wednesday, February 14, 2018 - 10:30am - 11:30am
William Lytton (SUNY Downstate Medical Center)
Multiscale modeling has arisen as a focus of computational systems biology, with the realization that genome, proteome, connectome, etceteromes, can become comprehensible only when placed in the context of explicit computer simulations. Measurements and activity patterns at one scale must be understood dynamically in the context of patterns at higher and lower scales. Nowhere is this more apparent than in the domain of brain ischemia, where manipulations at molecular levels are used, so far unsuccessfully, to protect cells that are otherwise at risk of death.
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