Wednesday, February 14, 2018 - 10:30am - 11:30am
William Lytton (SUNY Downstate Medical Center)
Multiscale modeling has arisen as a focus of computational systems biology, with the realization that genome, proteome, connectome, etceteromes, can become comprehensible only when placed in the context of explicit computer simulations. Measurements and activity patterns at one scale must be understood dynamically in the context of patterns at higher and lower scales. Nowhere is this more apparent than in the domain of brain ischemia, where manipulations at molecular levels are used, so far unsuccessfully, to protect cells that are otherwise at risk of death.
Monday, February 12, 2018 - 9:00am - 10:00am
R. David Andrew (Queen's University)
Neurons of the higher brain immediately undergo spreading depolarization (SD) in response to ischemia resulting from heart failure, traumatic brain injury or focal stroke. The current(s) driving SD remain unidentified. At SD onset, neurons cease firing, swell and can die within minutes. To account for the massive SD current, the channel has to be either densely distributed in the plasma membrane, display a high unitary conductance, or both. A study of pyramidal neurons using whole-cell voltage clamp (Czeh et al.
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