Ion dynamics

Thursday, February 15, 2018 - 3:00pm - 4:00pm
Geir Halnes (Norwegian University of Life Sciences (NMBU))
Spreading depression and several other pathological conditions are associated with changes in ion concentrations in the extracellular space (ECS) of the brain. To understand such pathologies, we need to understand the interplay between the mechanisms that govern ECS concentration dynamics. The dynamics of an ion species depends on (i) cellular output as well as ECS transport due to (ii) diffusion and (iii) electrical migration.
Thursday, February 15, 2018 - 9:00am - 10:00am
Maksim Bazhenov (University of California, San Diego)
A balance between excitation and inhibition is necessary to maintain stable brain network dynamics. Traditionally, seizure activity is believed to arise from the breakdown of this delicate balance in favor of excitation with loss of inhibition. Surprisingly, recent experimental evidence suggests that this conventional view may be limited, and that inhibition may play a prominent role in the development of epileptiform synchronization.
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