Wednesday, March 14, 2018 - 4:00pm - 4:25pm
Adam Stinchcombe (University of Toronto)
The Poisson-Nernst-Planck (PNP) equations can be used to describe cellular electrical activity. However, on domains where the space-charge layer is small, these equations are intractable and therefore it is useful to assume that the ionic solution is everywhere electrically neutral. The much more manageable electroneutral model results from a boundary layer analysis of the PNP equations.
Wednesday, March 14, 2018 - 3:30pm - 3:55pm
Owen Lewis (The University of Utah)
The gastric mucus layer is widely recognized to serve a protective function in the human stomach, shielding the epithelium and the gastric mucosa from the extremely low pH and digestive enzymes present in the stomach lumen. How this gel layer and the extreme pH gradient across it are maintained is not fully understood. Mucus secretion and swelling at the stomach wall are balanced by enzymatic degradation of the gel network at the lumen. All of these processes, as well as the rheology of the mucus itself are mediated by local pH, which is non-uniform throughout the layer.
Thursday, February 15, 2018 - 3:00pm - 4:00pm
Geir Halnes (Norwegian University of Life Sciences (NMBU))
Spreading depression and several other pathological conditions are associated with changes in ion concentrations in the extracellular space (ECS) of the brain. To understand such pathologies, we need to understand the interplay between the mechanisms that govern ECS concentration dynamics. The dynamics of an ion species depends on (i) cellular output as well as ECS transport due to (ii) diffusion and (iii) electrical migration.
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