DNA Knots

Wednesday, January 17, 2018 - 10:00am - 10:50am
F. Javier Arsuaga (University of California, Davis)
The three dimensional organization of genomes is a key player in multiple biological processes including the packaging and release of viral genomes. The genome of some viruses, such as bacteriophages or human herpes, is a double stranded DNA (dsDNA) molecule that is stored inside a viral protein capsid at a concentration of 200 mg/ml-800mg/ml and an osmotic pressure of 70 atmospheres. The organization of the viral genome under these extreme physical conditions is believed to be liquid crystalline but remains to be properly understood.
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