Chemical structure

Friday, April 30, 2010 - 1:25pm - 2:25pm
Anthony Kearsley (National Institute of Standards and Technology)
Chemical spectroscopy is an invaluable tool in commerce, public safety, health care, national security, and scientific research. In most cases a measurement expert with considerable experience using an ill-defined catalog of heuristic rules is required to optimize the instrument and to interpret the data. Using an expert is expensive, not always reproducible, and introduces uncontrolled bias to the measurement process. Numerical algorithms for nonlinear optimization can supplement, and perhaps even replace, the knowledge of the expert operator.
Monday, February 27, 2012 - 3:00pm - 3:45pm
Frederick Roth (University of Toronto)
Sometimes two mutations together cause a phenotype that is surprising given the effects of individual mutations. This phenomenon defines genetic interaction. Similarly, one drug can synergize with or antagonize the effects of another. I will describe early efforts at systematically mapping the network of interactions between antifungal chemical agents.
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