Cancer Evolution

Wednesday, June 6, 2018 - 11:00am - 11:30am
Jasmine Foo (University of Minnesota, Twin Cities)
It has been observed experimentally that epigenetic phenomena can induce temporary or reversible drug-resistant phenotypes in cancer cell populations. For example, changes in methylation status of DNA repair genes may impact the responsiveness of cells to chemotherapies. Although these phenomena may be transient, they can have lasting impact on the genetic evolution of a tumor. Short-term epigenetic adaptations may serve as temporary lifelines for a population until more permanent genetic resistance mechanisms can be established.
Thursday, September 14, 2017 - 11:20am - 11:50am
Georg Luebeck (Fred Hutchinson Cancer Research Center)
Biomarkers that drift differentially with age between normal and premalignant tissues, such as Barrett’s esophagus (BE), have the potential to improve the assessment of a patient’s cancer risk by providing quantitative information about how long a patient has lived with the precursor (i.e., dwell time).
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