Background: The CareLink™ database has been used to generate a large number of virtual patients that can be used for in silico testing.
Methods: Each virtual subject was trained from 20 days of CareLink™ data. Using data from the ASPIRE Clinical Trial 1 and from the MiniMed™ 670G hybrid closed-loop (HCL) study 2 , the virtual patients were validated. Insulin action speed and meal absorption rates used in the mathematical model were validated with published literature. Thereafter, a mathematical model was developed with a tailored parametric optimization method.