Experimental and Computational Approaches to Study Heterogeneity in Dormancy Induction

Monday, April 6, 2020 - 2:10pm - 2:40pm
Rec Center - Beacon Rm
Samira Azarin (University of Minnesota, Twin Cities)
Dormant tumor cells can persist in the body for years after treatment before reactivating and causing disease recurrence. Several signaling pathways and microenvironmental cues have been implicated in the induction and maintenance of breast cancer dormancy. However, it is not clear how different microenvironmental factors impinge on the core cell cycle framework to regulate dormancy or why only a subset of tumor cells experiencing the same environmental stress enters a dormant state. This talk will describe the development of experimental models and computational approaches to understand fundamental and conserved mechanisms regulating dormancy toward the long-term goal of designing effective therapeutic strategies to target dormant cells.