Countering Exhaustion in T Cell Immunotherapy

Monday, April 6, 2020 - 1:30pm - 2:10pm
Rec Center - Beacon Rm
Lance Kam (Columbia University)
Reliable production of T cells remains a barrier to full deployment of cellular immunotherapy. In particular, T cells from patients being treated for Chronic Lymphocytic Leukemia (CLL) exhibit signs of exhaustion including impaired activation and subsequent growth ex vivo. In this talk, we explore how the CLL disease state affects a range of T cell functions including migration and sensitivity to stimulation. Moreover, we demonstrate that T cell mechanobiology can be leveraged to rescue expansion of these cells ex vivo. Understanding the effects of CLL on cell function can thus lead to new strategies for improving and tailoring T cell immunotherapy.