Developing experimental and mathematical models to measure changes in tumor associate macrophage polarization in response to immunotherapy

Tuesday, April 7, 2020 - 2:15pm - 3:00pm
Lind 305
Elizabeth Wayne (Carnegie Mellon University)
Tumor associated macrophages (TAMs) are a significant player in cancer microenvironment. They can comprise 50%-80% of a solid tumor mass and M2, anti-inflammatory polarized TAMs are correlated with poorer clinical outcomes. Numerous therapeutic strategies attempt to modulate TAM polarization to decrease tumor growth. However, macrophage polarization is dependent on a number of intrinsic and extrinsic factors. Understanding the factors government TAM polarization can help us understand therapeutic response heterogeneity. Here the talk will discuss experimental models for deciphering the interplay of TAM polarization, drug accumulation, and tumor growth. Moreover, this talk will discuss ideas for developing models that work in tandem with experimental data. Being able to experimentally and mathematically model the effect of immunomodulatory drugs on TAM polarization could enhance decision making in personalized cancer treatment.