Tumor-Matrix Interactions in Early Ductal Invasions: integrating histology, mechanobiology and computational modeling

Tuesday, April 7, 2020 - 11:00am - 11:45am
Lind 305
Katarzyna (Kasia) Rejniak (Moffitt Cancer Center)
Progression from a ductal carcinoma in situ (DCIS) to an invasive tumor is a major step initiating a devastating and often lethal metastatic cascade. One sentinel event that initiates this process is the development of ductal microinvasions, i.e., small cohorts of tumor cells capable of invading the surrounding the extracellular matrix (ECM) leading to irreversible changes in tumor and stromal architecture. The formation of tumor microinvasions requires a combination of cell-ECM signaling and cell mechanical forces that together allow for breaching the basement membrane surrounding the duct.

We use the novel techniques of landscape pathology which combine advanced image analysis methods applied to patients’ histology data with multi-factorial classification methods, and integrate them with a hybrid agent-based mathematical model, to investigate the biomechanical interactions between the cells and the ECM fiber architecture, and microenvironmental physical and metabolic features that define tumor niche prone to microinvasions.