The Insulin Signaling Pathway and Growth Regulation

Thursday, June 7, 2018 - 10:00am - 10:50am
Lind 305
Peter Bates (Michigan State University)
We model the insulin signaling pathway as a signal from receptors in the cell membrane propagates to the nucleus via numerous molecules some of which are transported through the cell by molecular motors in a partially stochastic way. These molecular species interact and eventually regulate the transcription factor FOXO, which is partly responsible for inhibiting the growth of organs.

It is postulated that FOXO partially governs the plasticity of organ growth, thereby preserving the full function of essential organs at the expense of less crucial ones during starvation conditions. We present a mathematical model of this reacting and directionally-diffusing network of molecules and compare the predictions resulting from simulations with experimental data.