Chronic Hepatitis B virus and Liver fibrosis

Thursday, June 7, 2018 - 9:00am - 9:50am
Lind 305
Avner Friedman (The Ohio State University)
Hepatitis B virus (HPV) is a major global health problem that leads to liver fibrosis and failure. It affects more than 350 million people chronically. In this talk we introduce an extensive network with approximately 30 nodes which represents the interactions among cells, cytokines and the virus. We represent these interactions by a system of PDEs. The model describes the progression of HBV without treatment, and is then used to predict the results after treatment with combination of two drugs: IFN-α that decreases viremia, and adefovir that decreases viral load. A synergy map is developed which suggests at which ratio to take the two drugs in order to increase the efficacy of the treatment. This is joint work with Nourridine Siewe.