From Signaling to Movement -- Mathematical and Computational Problems in Cell Motility

Tuesday, June 5, 2018 - 10:00am - 10:50am
Lind 305
Hans Othmer (University of Minnesota, Twin Cities)
Cell locomotion is essential for early development,
angiogenesis, tissue regeneration, the immune response, and
wound healing in multicellular organisms, and plays a very
deleterious role in cancer metastasis in humans. Locomotion
involves the detection and transduction of extracellular
chemical and mechanical signals, integration of the signals
into an intracellular signal, and the spatio-temporal control
of the intracellular biochemical and mechanical responses that
lead to force generation, morphological changes and directed
movement. We will discuss some of the mathematical and
computational challenges that the integration of these
processes poses and describe recent progress on some component