Computational Analysis and Applications of Diffusion MRI

Tuesday, December 15, 2015 - 1:25pm - 2:25pm
Lind 305
Christophe Lenglet (University of Minnesota, Twin Cities)
Diffusion Magnetic Resonance Imaging (MRI) provides unprecedented insights into the wiring of the human brain. This non-invasive imaging technique, introduced in the mid-1980s, uses diffusing water molecules as microscopic probes for the three dimensional structure of axonal pathways. Large international consortia such as the Human Connectome Project (HCP) are currently underway to exploit diffusion MRI, in conjunction with other structural and functional imaging modalities, and ultimately elucidate the brain circuitry. Diffusion MRI raises many mathematical and computational challenges, because of the complexity of the data and the need for adequate models. In this talk, I will give an overview of the basic concepts behind this imaging modality, address topics such as white matter fiber orientation mapping and tractography, and describe their application to the study of neurodegenerative diseases.