RNA Folding: From Random Matrix Theory to Structure Prediction Algorithms
Monday, December 9, 2013 - 2:00pm - 2:50pm
Henri Orland (Commissariat à l'Énergie Atomique (CEA))
After reviewing some basic properties of RNA, we show how the problem of RNA folding can be formulated in terms of a matrix field theory. As a consequence, RNA secondary structures can be classified according to their topological genus. After presenting some combinatorics results about RNA structure, we present an overview of the genus distribution of all experimentally known RNA structures. These concepts are used to design two powerful algorithms for the prediction of RNA structures with pseudoknots.