Cell-based, Continuum and Hybrid Models of Tissue Dynamics

Tuesday, July 30, 2013 - 3:30pm - 4:30pm
Keller 3-180
Hans Othmer (University of Minnesota, Twin Cities)
Cell and tissue movement are essential processes at various stages in the life
cycle of multicellular organisms. Early development involves individual and
collective cell movement, leukocytes must migrate toward sites of infection as
part of the immune response, and in cancer directed movement is involved in
invasion and metastasis. The forces needed to drive movement arise from actin
polymerization, molecular motors and other processes, but understanding the
cell- or tissue-level organization of these processes that is needed to produce
the forces necessary for directed movement at the appropriate point in the cell
or tissue is a major challenge. We will focus both on the basic principles and
techniques in continuum mechanics at various levels of organization, as well as
on specific applications such as cell shape and motility, growth and deformation
of tissues, and cell- and tissue-level models of

Lecture Notes