Tutorial - Analyzing cellular networks: Moving from topological to attribute-driven analysis

Monday, February 27, 2012 - 10:15am - 11:15am
Keller 3-180
Mona Singh (Princeton University)
Proteins accomplish virtually all of their cellular functions via interactions with other molecules. High-throughput experimental technologies, along with computational
predictions, have resulted in large-scale protein interaction networks for numerous organisms. What can we learn about biological systems from these networks? In my talk, I will discuss a number of approaches we and others have developed for analyzing these networks in order to uncover cellular organization principles, and to reveal protein functions and pathways. I will focus on the increasing need to perform attribute-driven analysis, where systems-level measurements and knowledge about proteins and interactions are incorporated into computational methodologies.