Coarse-grained simulation studies of mesoscopic membrane phenomena<br/><br/><br/><br/>

Monday, November 3, 2008 - 11:15am - 12:00pm
EE/CS 3-180
Markus Deserno (Carnegie-Mellon University)
Lipid membranes exhibit a large spectrum of fascinating physical
behavior, spanning many orders of magnitude both in length- and time
scales. To cover this wide range, models of different resolution have
been developed, from atomistically resolved lipid representations to
triangulated fluid-elastic surfaces. In the intermediate regime of
about 100 nanometer length scale and micro- to millisecond time scale
mesoscopic coarse-grained models have recently covered much ground.
They can approach phenomena in which cooperativity between several
proteins are crucial, while still preserving the essence of many lipid
degrees of freedom (area density, order, tilt, composition, etc.),
whose coupling is deemed relevant in many biological situations,
notably the raft question. I will describe in more detail a
particular solvent-free coarse-grained model recently developed by us
and illustrate its applicability to a wide variety of phenomena, among
them pore-formation by amphipathic peptides, protein aggregation on
critically mixed bilayers, and membrane vesiculation driven by
curvature-imprinting proteins.
MSC Code: