Closing the Loop on Protein-DNA Interactions

Monday, September 17, 2007 - 3:00pm - 4:00pm
EE/CS 3-180
Stephen Levene (University of Texas at Dallas)
The formation of DNA loops by proteins bound at distant sites along a single
molecule is an essential mechanistic aspect of many biological processes
including gene regulation, DNA replication, and recombination. The
biological importance of DNA loop formation is underscored by an abundance
of architectural proteins in cells such as HU, IHF, and HMGs, which
facilitate looping by bending the intervening DNA between cognate
protein-binding sites. We have developed a rigorous theory for DNA loop
formation that connects the global mechanical and geometric properties of
both DNA and protein, including previously neglected phenomena such as
conformational flexibility of protein domains. Applications to problems in
gene regulation and DNA recombination both in vitro and in vivo will be

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