Understanding and Using Bacterial Sensory Systems

Tuesday, April 22, 2008 - 2:00pm - 2:40pm
EE/CS 3-180
Antonis Papachristodoulou (University of Oxford)
Applying results from dynamical systems, control and optimization, we
develop new approaches for designing experiments to elucidate the
biochemical network structure of the chemotaxis mechanism in R.
sphaeroides. Biological information and data is used to create initial
models (model determination); an experiment is then designed in order
to discriminate between these models; and a model invalidation
procedure closes the loop. This way we can develop an understanding of
the underlying biochemical network structure and appreciate the
properties and architecture of bacterial sensory systems in general. A
Synthetic Biology approach can then be used to redesign such networks
for improved or modified functionality.