Fundamental Limitations on Noise Reduction in the Cell

Thursday, April 24, 2008 - 2:00pm - 2:40pm
EE/CS 3-180
Glenn Vinnicombe (University of Cambridge)
It is well known that, for a molecule being produced in an unregulated manner and degraded exponentially (constitutive gene expression for example) the intrinsic noise in the molecule number will be such that variance equals the mean. This talk will establish fundamental limits on the amount of noise reduction that can be obtained by regulation when delays in the mechanism (due to transport and the finite time required to synthesize intermediate molecules) and when that mechanism has limited information carrying capacity in the sense of Shannon (due to itself involving finite numbers of molecules).