Generic Approach to Construction of System Design Space

Tuesday, April 22, 2008 - 9:30am - 10:10am
EE/CS 3-180
Michael Savageau (University of California, Davis)
Determining quality of performance for a biological system is critical to identifying and elucidation its design principles. This important task is greatly facilitated by enumeration of regions within the system's design space that exhibit qualitatively distinct function. First, I will review a few examples of design spaces that have proved useful in revealing design principles for elementary gene circuits. Then I will present a recently developed approach to the generic construction of design spaces, illustrate its application to common classes of biochemical network motifs, and test predictions for a specific class with experimental data from human erythrocytes.