Engineering Protein Structure and Function with Theoretical Protein Design

Monday, January 14, 2008 - 2:00pm - 2:30pm
EE/CS 3-180
Jeffery Saven (University of Pennsylvania)
Protein design opens new ways to probe the determinants of folding, to facilitate the study of proteins, and to arrive at novel molecules, materials and nanostructures. Recent theoretical methods for identifying the properties of amino acid sequences consistent with a desired structure and function will be discussed. Such methods address the structural complexity of proteins and their many possible amino acid sequences. Several computationally designed protein-based molecular systems will be presented that have been experimentally realized, including novel proteins tailored to accommodate nonbiological cofactors.

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