Part II: Implications of Base Sequence-Dependent Structural Information on Larger-Scale Genetic Control

Saturday, September 15, 2007 - 10:30am - 11:30am
EE/CS 3-180
Wilma Olson (Rutgers, The State University of New Jersey)

    A. Quantitation of local, sequence-dependent properties of DNA

  1. Low resolution models, including knowledge-based

  2. Linear, sequence-dependent three-dimensional structures

B. Effects of sequence on ring closure properties of closed

  1. Sequence-dependent factors that enhance the formation of
    tight minicircles and loops

  2. Mechanics of superhelix formation: roles of bending,
    twisting, and base-pair displacement

  3. Nucleotide looping and global folding of RNA

C. Effects of sequence on the equilibrium structures and
normal modes of cyclized DNA

  1. Constrains of bound proteins on global structure and

  2. Nucleosome positioning sequences and minichromosomes