Campuses:

Stochastic aspects of actin filament dynamics<br/><br/><br/><br/>

Tuesday, May 13, 2008 - 11:15am - 12:15pm
EE/CS 3-180
Hans Othmer (University of Minnesota, Twin Cities)
Actin polymerization and network formation are key processes in cell
motility. Numerous actin binding proteins that control the dynamic
properties of actin networks have been studied and models such as the
dendritic nucleation scheme have been proposed for the functional
integration of at least a minimal set of such regulatory
proteins. In this talk we will describe recent work on
the evolution of the distribution of filament lengths and nucleotide
profiles of actin filaments from both the deterministic and
stochastic viewpoints. For the latter we develop a master
equation for the biochemical processes involved at the individual
filament level and simulate the dynamics by generating numerical
realizations using a Monte Carlo scheme. A new computational algorithm
that is far more efficient than standard methods will also be
described.