Interaction of Lipid Bilayers with Inorganic Surfaces: Experiments to Modeling

Friday, April 4, 2008 - 2:25pm - 3:25pm
Vincent 570
Aravind Rammohan (Corning Incorporated)
Joint work with David R. Heine and Jitendra Balakrishnan.

Lipid bilayers typically serve as the scaffold for trans membrane protein receptors. These membrane protein receptors are targets for atleast 50% of the drug molecules developed by pharmaceutical companies. Drug development and testing typically is carried out in an invitro environment with these lipid membranes deposited on some synthetic surface organic or inorganic. Here we present details of the interactions between lipid bilayers and inorganic surfaces. The approach adopted to develop an understanding of these interactions has been a combination of a multiscale modeling framework in conjunction with specific experimental effort to complement the modeling effort. The multiscale modeling effort involves modeling the membrane surface interactions in detail at an atomistic level to looking at macroscopic membrane dynamics on surfaces with specific topologies. The experimental effort involves a combination of Surface Force Apparatus (SFA) and Atomic Force Microscopic (AFM) measurements to generate these insights. The talk will focus specifically on the role of surface topology in modulating membrane surface interactions.