Campuses:

Team 5: Models of Human Physiology, and Randomized Clinical Trials

Monday, August 1, 2005 - 11:20am - 11:40am
EE/CS 3-180
David Ross (Kaiser Permanente)
Randomized clinical trials are the central feature of modern medical methodology. In an RCT, two or more populations of patients who are statistically identical on the relevant dimensions are given different medical treatments. The results are then recorded, and are used to establish medical practice. The Archimedes Project of Kaiser Permanente has undertaken the development of a mathematical model of human physiology that will complement RCTs. The purpose of the model is to integrate data from various RCTs, then to predict health outcomes for populations not specifically considered in any particular RCT, perhaps for treatments not specifically considered in any particular RCT. What sort of model(s) of human physiology are appropriate for this purpose?

References:

Eddy, D., and Schlessinger, L.,Diabetes Care 26:3102-3110, 2003

Eddy, D., and Schlessinger, L.,Diabetes Care 26:3093-3101, 2003