Comparing Normalization Methods Based on Splice Array Experiments

Wednesday, October 1, 2003 - 11:00am - 11:25am
Keller 3-180
Jean Yang (University of San Francisco)
There are many sources of systematic variation in microarray experiments that affect measured gene expression levels. Normalization is the term used to describe the process of removing such variations. In this talk, I will describe a set of experiments based on splice-specific microarrays. These arrays provide a basis to investigate the effect of mutations and other factors on splicing events in the creation of mature mRNA. In particular, the design of these arrays provides a platform for comparing the performance of different normalization methods.