Gene Clusters in Comparative Genomics: Accident or Design?

Wednesday, October 22, 2003 - 1:30pm - 2:20pm
Keller 3-180
Dannie Durand (Carnegie-Mellon University)
Large scale gene duplication, the duplication of whole genomes and subchromosomal regions, is a major force driving the evolution of genetic functional innovation. Whole genome duplications are widely believed to have played an important role in the evolution of the maize, yeast and vertebrate genomes. Two or more linked clusters of similar genes found in distinct regions on the same genome are often presented as evidence of large scale duplication. However, as the gene order and the gene complement of duplicated regions diverge progressively due to insertions, deletions and rearrangements, it becomes increasingly difficult to distinguish remnants of common ancestral gene order from coincidental similarities in genomic organization. In this talk, I present computational approaches to validating gene clusters in comparative genomics.