Analysis of Horizontal Gene Transfers of Potential Relevance to Microbial Virulence

Thursday, October 23, 2003 - 1:30pm - 2:20pm
Keller 3-180
Fiona Brinkman (Simon Fraser University)
We have been using genome-wide bioinformatic approaches to identify horizontal gene transfers that are of interest for their potential role in bacterial virulence and the evolution of pathogenic microbes. Analyses of both bacteria-eukaryotic and bacteria-bacteria gene transfers are summarized, revealing possible patterns in the types of genes most often transferred between species. The implications are discussed, both in the context of the evolution of virulence and what is likely the most effective approach to control infectious disease agents.