Measures of Conserved Synteny

Thursday, October 23, 2003 - 11:00am - 11:50am
Keller 3-180
Elizabeth Housworth (Indiana University)
Measures of conserved synteny are important for estimating the relative rates of chromosomal evolution in various lineages. We present a natural way to view the synteny conservation between two species from an Oxford grid--an r x c table summarizing the number of orthologous genes on each of the chromosomes 1 through r of the first species that are on each of the chromosomes 1 through c of the second species. This viewpoint suggests a natural statistic, which we call syntenic correlation, designed to measure the amount of synteny conservation between two species. This measure allows syntenic conservation to be compared across many pairs of species. We also discuss incorporating the dependency of the numbers of orthologues observed in the chromosome pairings between the two species into the estimates of the true number of conserved syntenies given the observed number of conserved syntenies.