Tissue Growth in Cell-Contracted Biopolymer Scaffolds

Thursday, June 26, 2003 - 1:00pm - 2:00pm
Lind 409
Robert Tranquillo (University of Minnesota, Twin Cities)
We have attempted to develop a tissue-engineered artery and heart valve based on the approach of entrapping tissue cells within a forming collagen gel. The ability to harness the cell traction-induced contraction of the network of collagen fibrils to obtain the desired alignment of fibrils and cells will be described and explained. Recent efforts to drive compositional remodeling following the structural remodeling obtained via mechanically-constrained contraction, using fibrin as an alternative biopolymer to collagen for cell entrapment, with the goal of attaining the requisite mechanical properties, will be presented. Unlike the early structural remodeling, the subsequent compositional remodeling and associated tissue growth that occurs in fibrin presents major modeling challenges.

Recent relevant publications:

A novel implantable collagen gel assay for fibroblast traction and proliferation during wound healing.