Analysis of Drug Effects on Spatial Patterns of Gene Expression in MR Neuroimaging and Microscopy

Friday, October 13, 2000 - 10:15am - 11:00am
Keller 3-180
Nick Lange (McLean Hospital)
In this talk, I will discuss recent findings on automatic identification of c-fos gene expression in rat thalamus, amygdala and nucleus accumbens post administration of typical and atypical antipsychotics, a benzodiazepine and a sedative, all compared to a control condition. I will provide background for these types of experiments, including some current work in pharmacological magnetic resonance imaging (phMRI). Relevant quantitative analytical considerations lead one to question certain general methodological approaches taken currently in similar animal and human microscopy. Additional recent results will also be presented on one such issue: How to count neurons in human neocortex -- presenting a challenge to so-called unbiased optical disector stereological methods.