Mathematical Models in the Study of Epithelial Transport

Thursday, February 11, 1999 - 2:30pm - 3:00pm
Keller 3-180
Raymond Mejia (National Institutes of Health)
Research in epithelial transport is being advanced by the identification, location, and study of proteins that allow for transport of species through lipid membranes.

Models of the urine concentrating mechanism are now used to quantitate the effect of changes in these transporters within normal and pathological states. Furthermore, the distribution of certain proteins within the rat kidney (e.g. AQP1, AQP2, BSC1, TSC, UT-A1, UT-A2, ClC-K1) is utilized to estimate transport parameters as well as identify renal morphometry.

We shall describe examples of the use of tools of molecular biology in conjunction with new physiological observations to refine the models.