[I.] On the meaning of self, and why we make self-reactiveresponses<br/><br/>First of two lectures, with subtitles<br/><br/>Overall Abstract: Homunculi and Golems: Determinism and Unpredictability in the Immune System
Tuesday, October 20, 1998 - 11:00am - 12:00pm
Eli Sercarz (La Jolla Institute for Allergy & Immunology)
Potential reactivity to self antigenic determinants is not an anomaly but a natural consequence of the rules of positive and negative selection, and the nature of the degeneracy of specificity of the T cell receptor. Many T cells exist with self-reactive capability and discussion will focus on the initiation, propagation and regulation of aggressive self-directed responses. The hypothesis will be presented that in addition to the tight-wired regulatory systems (i.e., homuncular after Irun Cohen) there are many features of the immune system that are essentially unpredictable. The widespread presence of degeneracy and redundancy in the system further adds to the unpredictability of response in a particular individual.