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Cardiac Conduction: An Interplay Between Membrane Processes and Structural Properties

Wednesday, March 11, 1998 - 9:30am - 10:30am
Keller 3-180
Yoram Rudy (Case Western Reserve University)
Impulse propagation in the heart results from interaction between cellular ionic processes and passive structural properties of the myocardium. Using a multicellular theoretical fiber model, the interplay between membrane ionic processes and gap junction properties during action potential propagation will be explored. We will characterize the role of different ion channels in normal and abnormal conduction. The robustness of conduction under a variety of conditions will be quantitatively characterized in terms of a safety factor for conduction.