Calcium Triggers Secretion, But Which Calcium and How?
Thursday, February 12, 1998 - 4:30pm - 5:20pm
Arthur Sherman (National Institutes of Health (NIH))
It is well established that calcium is the prime trigger for secretion, both in neurons (synaptic transmission) and in neuro-endocrine cells (hormone secretion). However, cell calcium is divided into multiple pools by buffering, spatial gradients, sequestration in internal organelles, and spatial co-localization of ion channels and calcium-binding effector sites. Differences in these features and consequent differences in the dynamics of neuro-transmitter and hormone secretion will be addressed.