Mechanisms of Synaptic Enhancement and Depression

Wednesday, January 21, 1998 - 9:30am - 10:30am
Keller 3-180
Arthur Sherman (National Institutes of Health (NIH))
Mechanisms at the terminal level for synaptic enhancement on several time-scales (facilitation, augmentation, post-tetanic potentiation) and depression will be discussed. Issues to be considered will include the roles of residual free Ca2+ and residual Ca2+ bound to memory proteins, and the roles of domain and macroscopic Ca2+. We will also explore to what extent synaptic depression can be accounted for in terms of vesicle depletion and resupply.