Network Model of Theta Rhythm and Temporal Coding in the Hippocampus

Monday, January 19, 1998 - 9:30am - 10:30am
Keller 3-180
Misha Tsodyks (Weizmann Institute of Science)
The firing patterns of pyramidal cells in the CA1 and CA3 regions of the rat hippocampus are related to both the location of the animal in the environment and the theta rhythm, which dominates the hippocampal EEG during exploratory movements. O'Keefe and Recce (1993) have observed that the spatially selective firing of pyramidal cells tends to advance to earlier phases of the theta rhythm as a rat passes through the place field of a cell. The relative timing of a cell's action potential could therefore carry information about the rat's location which would constitute an interesting example of a temporal code. I will present a network model which generates this effect as resulting from the pattern of internal connectivity between pyramidal neurons in the Hippocampus.