**The Multiscale Problem in
Systems Biology**

**Computational Models of
Chemical Reaction Systems**

**Stochastic Simulation
Algorithm**

**Stochastic Simulation
Algorithm**

**Stochastic Simulation
Algorithm**

**A Closer Look at the
Multiscale Challenges for Heat Shock Response**

**Stochastic Partial
Equilibrium Approximation**

**Foundations of SPEA (continued)**