Multiscale Stochastic Simulation Algorithm with Stochastic Partial Equilibrium Assumption for Chemically Reacting Systems

The Multiscale Problem in Systems Biology

Computational Models of Chemical Reaction Systems

Stochastic Simulation Algorithm

Stochastic Simulation Algorithm

Stochastic Simulation Algorithm

Hybrid Methods

A Closer Look at the Multiscale Challenges for Heat Shock Response

Stochastic Partial Equilibrium Approximation

Foundations of SPEA

Foundations of SPEA (continued)

The Multiscale Stochastic Simulation Algorithm

Down-Shifting Method

Heat Shock Response Model

MSSA Heat Shock Response Model Results